NMN Supplements

In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.¹ The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration.^2,3 Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.⁴

Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.⁵ In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”⁶ Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.^7,8

By middle age, our NAD+ levels have plummeted to half that of our youth.⁹ Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.^10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).^12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.⁶

Taken orally, NMN is rapidly absorbed and converted to NAD+.¹⁴ In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.¹⁵ Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.¹⁶

Pathways to NMN in the Human Body

A veritable symphony of interlocking transformations allows NAD+ to be both synthesized and regulated in the body. It is well known that vitamin B₃ is a building block for Nicotinamide adenine dinucleotide (NAD+). It is also widely recognized that NMN is a potent precursor for NAD+. Though NMN is naturally found in small amounts in fruits and vegetables such as avocados, broccoli, cabbage, edamame, and cucumbers¹⁷, in mammals most NMN is synthesized from vitamin B₃ in the form of nicotinamide. At the center is nicotinamide phosphoribosyltransferase (NAMPT), an essential rate-limiting enzyme that catalyzes the conversion from nicotinamide to NMN, which exists in both an intracellular (iNAMPT) and extracellular form (eNAMPT).¹⁸ The extracellular form has higher enzymatic activity than the intracellular form and has been found in blood plasma, seminal plasma and cerebrospinal fluid in humans.^19,20 In addition, eNAMPT appears to be produced by a wide array of cell types—including fat (adipocytes), liver (hepatocytes), white blood cells (leukocytes and monocytes), and heart and brain cells (cardiomyocytes and glia cells).²¹ Like NAD+ and NMN, eNAMPT declines with age. Both white and brown adipocytes actively secrete eNAMPT, suggesting that fatty tissue may be a modulator of NAD+ biosynthesis.⁶ Adipose tissue actively secretes extracellular vesicles (EVs) that are enriched with NMN, and can circulate through the plasma. EVs are membrane-derived particles surrounded by a phospholipid bilayer that are released by cells in the human body.²² These EVs not only protect their cargo, they can deposit their payload where needed.²³

NMN and NR dance together. NMN can be converted by the body to NR, which then enters cells, and is converted back to NMN by an enzyme called nicotinamide riboside kinase (NRK). More recently, an “elusive’ transporter was discovered, which can transport NMN directly into cells.²⁴ NMN is transported across cell membranes directly into the cytoplasm of the cell, by an enzyme called Slc12a8. Uptake pathways of NMN vary with tissue types, and interestingly, Slc12a8 expression is about 100-fold times higher in the small intestine of mice than the brain or adipose tissue. Researchers speculate that the gut microbiome, and certain resident bacteria within it, may produce NMN.²⁵

NMN levels fall with age, and aging itself has also been shown to significantly compromise the body’s conversion of NMN to NAD+.²⁶

Abundant Evidence for Anti-aging and Health-Enhancing Effects of NMN

Looking Forward: NMN and Human Health

NMN is clearly a murine fountain of youth. But what about humans? Shin-ichiro Imai has said that NMN may improve adult human metabolism, rendering it more like that of someone ten or twenty years younger.³⁴ His team is now studying NMN in humans. David Sinclair, Harvard University’s noted anti-aging researcher, whose research on resveratrol, NAD+ and sirtuins is world renowned, is also conducting human trials. He is taking NMN himself; he has said his lipid profile has improved dramatically and he feels more energetic and that his blood markers, at nearly 60 years old, are closer to those of a 31-year-old.^35,36

An interesting question is the delivery system for oral NMN: the EVs that transport the molecule through plasma in the body are liposomes. A liposomal version of NMN may well mimic the body’s own transport system, enhancing uptake and delivery, as science advances its understanding of the holy grail of reversing aging.

Biography

•

Christopher Shade, PhD, founder and CEO of Quicksilver Scientific, continues to be the driving force of development and innovation. Dr. Shade’s vast depth and breadth of knowledge, passion for healing, and intuitive understanding of chemistry and biology are reflected in Quicksilver Scientific’s well-designed detoxification protocols, unique supplement delivery systems, and patented mercury speciation test. Dr. Shade earned his PhD from the University of Illinois Urbana-Champaign and his undergraduate degree in Environmental Chemistry is from Lehigh University.

Dr. Shade is a recognized expert on mercury and liposomal delivery systems. He has lectured and trained doctors in the United States and internationally on the subject of mercury, heavy metals, and the human detoxification system. Dr. Shade’s current focus is on the development of cutting-edge, lipid-based delivery systems for nutraceuticals, such as liposomes and micro-emulsion systems, to address the growing need of high-quality, affordable detoxification solutions.

Sort by:

10 products

NMN with Resveratrol 2000 mg General SUPPS247

NMN with Resveratrol 2000 mg by MOM Nutrix

$209.95

Mom Nutrix NMN with Resveratrol (2000mg) is a premium longevity and cellular health supplement scientifically formulated to support healthy aging, metabolic function, and cognitive performance. Each serving delivers a potent combination of Beta-Nicotinamide Mononucleotide (NMN), Resveratrol, and Trimethylglycine (Betaine Anhydrous)—ingredients known to promote NAD⁺ production, mitochondrial efficiency, and overall vitality.

Manufactured in the USA under GMP-certified standards, this supplement is vegan-friendly, non-GMO, gluten-free, and contains no artificial preservatives, ensuring high quality and purity with every capsule.

Key Uses:

Supports healthy aging and cellular longevity
Aids metabolism and energy regulation
Promotes brain function, clarity, and cognitive health
Enhances cellular repair and DNA integrity
Contributes to cardiovascular and liver health

Core Benefits:

NMN (1000mg): A direct NAD⁺ precursor that plays a key role in energy metabolism, cellular health, and DNA repair
Resveratrol (500mg): A powerful antioxidant that supports sirtuin activation, healthy inflammation response, and cardiovascular wellness
Trimethylglycine (500mg): Supports methylation processes, liver detox, and overall metabolic balance
Longevity Support: May reduce signs of aging at the cellular level by replenishing essential energy molecules
Mental Performance: Assists in enhancing memory, focus, and cognitive function
Clean Formula: Non-GMO, gluten-free, vegan capsules with no added preservatives

Supplement Facts (Per Serving – 2 Capsules)

β-Nicotinamide Mononucleotide (NMN) – 1000 mg
Resveratrol – 500 mg
Betaine Anhydrous (Trimethylglycine) – 500 mg
Servings Per Container: 30
Capsules Per Bottle: 60

Product Highlights

✓ 99.8% Standardized Purity
✓ Made in the USA
✓ GMP Certified Manufacturing
✓ No Preservatives, Artificial Colours, or Additives
✓ Vegan & Gluten-Free

Disclaimer: This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Always consult with your healthcare professional before starting any new supplement, especially if you are pregnant, nursing, or taking medications.

Resveratrol Ultra High Purity Antioxidants SUPPS247

Ultra High Purity Resveratrol Capsules

$109.95

Welltech GHK Collagen Peptide Cooper Collagen Welltech

Welltech GHK Collagen Peptide Powder

$69.95

Collagen Copper Peptide GHK is a powdered formulation designed to increase your body's natural production of Collagen Peptide. Collagen Peptide will assist your body in healing damaged tissue and in the delivery of copper to and from cells to support healing.

This product is an innovative powdered formulation, engineered with scientific technology and clinical research which contains the highly beneficial copper peptide GHK. GHK copper is a naturally occurring copper tripeptide, which is produced in the body in response to damaged tissue injury, assisting delivery of copper to and from cells to support the healing process. As we age our body’s ability to produce this peptide decreases and adequate copper regulation can decline which can be a reason for slower repair in the older population. Supplementing this bioidentical endogenous copper peptide is shown to support our body’s natural levels to generate cellular healing and repair.

Increased collagen synthesis: the amount of collagen in your body will increase therefore you will have faster and more effective repairs.
Activation of stem cells: Activating and supporting healthy stem cells are so important because they're responsible for a great deal of the healing process within the body.
Encourages healing and repair of wounds and damaged tissue
Improved cognitive function
Assists in hair regrowth and thickness
Improved skin complexion
Reduced inflammation and increased antioxidant enzymes
Stimulation of healthy blood vessels

Collagen Peptide Copper GHK is unflavoured giving you the option to mix\pair with your supplements of choice. The best supplement to mix would be collagen-based protein for added joint and connective tissue repair. Alternatively, if combined with NMN it would be excellent as an age-defying combo and support skin & hair health. With numerous studies supporting the many impressive benefits COLLAGEN PEPTIDE COPPER GHK can provide, this exceptional product is like nothing else in the supplement market and it is specifically designed to RESTORE, REJUVENATE and REGENERATE

HPN NAD+ Booster (NAD3) Anti Aging Antioxidants SUPPS247

NAD 3 by High Performance Nutrition

From $119.95

NMN by Primabolics

$89.95

NMN 500mg- Boost NAD-Anti-Aging Cellular Repair & Healthy(3 Packs 360 Lozenges)

$699.95

Experience the power of NMN 500mg, a supplement designed to boost NAD (Nicotinamide Adenine Dinucleotide) levels and promote healthy aging. This pack includes three bottles, totaling 360 lozenges for your convenience. NMN Max" combined with "NAD Support" supplements aims to maximize the benefits of NMN (Nicotinamide Mononucleotide) and directly support NAD+ (Nicotinamide Adenine Dinucleotide) levels in the body. Here are some potential benefits of this combination:

Key Benefits:

Enhanced NAD+ Production: NMN is a direct precursor to NAD+, and its supplementation can increase NAD+ levels in the body. Adding NAD Support, which may include other precursors or cofactors, could further enhance NAD+ synthesis and availability.
Improved Cellular Energy: NAD+ is crucial for mitochondrial function, which is responsible for producing energy in cells. Higher NAD+ levels can lead to improved cellular energy and vitality.
Supports Healthy Aging: With aging, NAD+ levels naturally decline, leading to various age-related issues. By boosting NAD+ levels, this combination may help alleviate some aging signs and support healthier aging processes.
DNA Repair and Cellular Health: NAD+ plays a vital role in DNA repair and the maintenance of genomic stability. Enhanced NAD+ levels could support better cellular repair mechanisms, potentially reducing the risk of age-related diseases.
Metabolic Health: NMN and NAD Support may improve insulin sensitivity and overall metabolic function, which can be beneficial for maintaining healthy blood sugar levels and preventing metabolic disorders.
Neuroprotection: NAD+ has a role in brain health and function. This combination might offer neuroprotective benefits, potentially aiding in the prevention or management of neurodegenerative conditions.
Physical Performance and Endurance: Some evidence suggests that NMN can enhance physical performance and endurance. This effect might be amplified with additional NAD Support.
Anti-Inflammatory Effects: NAD+ has been associated with reduced inflammation, which is a key factor in many chronic diseases.
Cardiovascular Health: Enhanced NAD+ levels can support cardiovascular health by maintaining healthy blood vessels and cardiac function.

Take advantage of the benefits of NMN 500mg to support NAD levels, promote healthy aging, boost energy metabolism, maintain brain health, and assist in DNA repair. This three-pack of lozenges ensures you have an ample supply to incorporate into your daily wellness routine.

Fisetin 100mg by Double Wood Supplements

$99.95

Fisetin 100mg by Double Wood Supplements is a natural bioflavonoid polyphenols supplement, offering a range of health benefits aimed at supporting healthy aging and overall well-being. Each bottle contains 60 capsules of Fisetin, a compound similar to other beneficial polyphenols like Apigenin, Luteolin, and Quercetin. Fisetin is known for its anti-aging properties, aiding in promoting cell efficiency and overall vitality. Classified as a "Senolytic Agent," it helps the body clear away damaged or potentially harmful cells, contributing to healthier aging. Furthermore, as a powerful polyphenol, Fisetin supports organ health, brain health, mood stability, as well as blood pressure and circulation. This supplement is ideal for those seeking natural support for longevity and optimal health.

Key Advantages:

Anti-Aging Support: Helps in promoting healthy aging and cell efficiency.
Natural Senolytic Agent: Aids the body in clearing away damaged cells, contributing to healthier aging processes.
Powerful Polyphenol: Offers broad health benefits, including support for organ and brain health.
Supports Brain Health: Contributes to cognitive well-being and mood stability.
Benefits Blood Pressure and Circulation: Helps in maintaining healthy blood pressure levels and circulatory health.
Promotes Overall Vitality: Aids in enhancing general well-being and physical health.
High-Quality Ingredients: Made with pure Fisetin, ensuring a potent and effective supplement.
Convenient Capsule Form: Easy to incorporate into daily health routines.
Suitable for a Variety of Diets: A natural supplement that fits into many dietary plans.
Research-Backed Benefits: The efficacy of Fisetin is supported by various studies.

Fisetin 100mg by Double Wood Supplements is an excellent choice for anyone looking to support their health naturally, particularly in the areas of aging, brain health, and overall physical well-being.

Disclaimer: This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use, especially if pregnant, nursing, on medication, or have a medical condition. Keep out of reach of children. Do not exceed recommended dosage. Statements are not evaluated by the FDA or TGA. Store in a cool, dry place.