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The Relationship Between NMN, Sleep, and Circadian Rhythms

By Gagan Bajwa  •   2 minute read

The Relationship Between NMN, Sleep, and Circadian Rhythms

The Connection Between NAD+ and Sleep

To understand the relationship between NMN and sleep, it's essential to consider NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme involved in various cellular processes, including energy production. NAD+ levels naturally decline with age, potentially affecting sleep and circadian rhythms in the following ways:

  1. Energy Metabolism: NAD+ is essential for energy metabolism, which influences the body's ability to regulate sleep-wake cycles.

  2. Sirtuins: NAD+ supports sirtuins, a group of proteins known to play a role in circadian rhythm regulation and cellular repair processes during sleep.

NMN and Sleep Quality

NMN is a precursor to NAD+ and is believed to increase NAD+ levels when ingested. Here's how NMN might influence sleep quality:

  1. Enhanced Cellular Health: NMN supplementation may support cellular health, including the function of mitochondria (the cell's energy producers), which can indirectly impact sleep quality.

  2. Circadian Rhythm Regulation: NMN's potential effects on NAD+ and sirtuins may help regulate circadian rhythms, promoting more consistent sleep-wake patterns.

  3. Mitigating Sleep Disorders: Some sleep disorders are associated with disruptions in NAD+ metabolism. NMN's role in supporting NAD+ levels could potentially help mitigate such disorders.

Research on NMN and Sleep

While research on the direct relationship between NMN and sleep is still in its early stages, several studies have provided insights into related areas:

  1. Animal Studies: Some animal studies have suggested that NMN supplementation can improve sleep quality and help maintain circadian rhythms, potentially delaying age-related sleep disturbances.

  2. Circadian Rhythm Effects: NMN's influence on circadian rhythms has been observed in animal models, hinting at its potential to support more regulated sleep patterns.

  3. Human Trials: Human clinical trials are ongoing to investigate NMN's effects on various aspects of health, including sleep. These trials aim to provide more definitive insights into the relationship between NMN and sleep in humans.

Considerations and Future Research

It's important to note that while the preliminary findings are promising, more research is needed to fully understand the impact of NMN on sleep quality and circadian rhythms in humans. Individual responses to NMN may also vary.

Before incorporating NMN into your sleep regimen, consult with a healthcare professional to ensure it aligns with your health goals and needs. Additionally, consider other factors that influence sleep, such as lifestyle, sleep hygiene, and stress management.


NMN's potential influence on sleep quality and circadian rhythms is an exciting area of research that holds promise for those seeking to optimize their sleep patterns and overall well-being. As the scientific understanding of NMN and its effects on sleep continues to evolve, it's essential to stay informed about the latest research findings and consult with healthcare professionals to make informed decisions regarding NMN supplementation as part of a holistic approach to improving sleep quality and maintaining healthy circadian rhythms.

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