Diosgenin is an extract of wild yam but also found in ginger and fenugreek. It elicits a broad range of beneficial effects on training and displays some promising potential to enhance athletic performance. Much like turkesterone and ecdysterone, diosgenin is able to encourage lean phenotype by acting directly in muscle and fat tissues and is a relatively underutilised natural plant steroid. Diosgenin enhances the production of DHEA, an androgen that can encourage GLUT-4 translocation (sugar uptake into muscle cells as an energy source). Diosgenin works directly in muscle fibres and also encourages AMPK activation, which increases metabolism, enhances utilisation of fat as an energy source via fatty acid oxidation and heightens insulin sensitivity.
Laxogenin is derived from Smilax Sieboldii which belongs to a group of compounds called brassinosteroids. Brassinosteroids are responsible for the regulation of genes and growth in plants. Some research indicates that laxogenin can have a muscle building effect by improving protein synthesis and increasing nitrogen retention. This leads to a faster recovery rate after strenuous exercise.
Epicatechin is a flavonoid, found in trace amounts from some known food sources including dark chocolate green tea. Several studies have discovered a number of physiological benefits that Epicatechin has when used in conjunction with exercise. It has a propensity to inhibit myostatin (a protein in the body which limits the level of muscle growth) and can significantly increase follistatin. As a result of this it has the ability to enhance muscle growth and strength. Other benefits include increased nitric oxide production, leading to improved blood flow and vascularity. It can also aid with increased endurance and delay muscle fatigue during exercise. Therefore, Epicatechin is a vital ingredient in this innovative formula for delivering added muscularity and enhancing performance.
Epidermal-like growth factor is a protein that stimulates cell growth and differentiation by binding to and activating the EGF receptor. Research suggests that epidermal growth factor serves as a critical growth factor in enhancing skeletal muscle cell proliferation and differentiation. Studies also show substantial increases in glucose tolerance, insulin sensitivity and glucose uptake by skeletal muscle. Furthermore, the EGF receptor has been shown to regulate expression of the IGF-1 receptor (IGF-1R), which is well known for its role in modulating muscle growth.